What Is a Repeated-Dose Toxicity Test?

Repeated-dose toxicity tests are important in vivo toxicity studies conducted to evaluate the toxic effects that may result from the repeated administration of a substance over a specific period of time. These studies play a critical role in the safety assessments of pharmaceuticals, biocidal products, chemical substances, pesticides, medical devices, and industrial products.

At NanoTox, we offer internationally recognized in vivo toxicity testing services using infrastructure compliant with GLP (Good Laboratory Practice) standards.

Purpose of the Repeated-Dose Toxicity Test

Repeated-dose toxicity studies aim to determine the effects that the tested substance may cause on an organism as a result of repeated exposures over a specific period. Through these studies, target organ toxicity, systemic effects, and safe dose ranges can be evaluated.

The data obtained plays a significant role in:

• Product safety assessments,
• Risk analyses,
• Regulatory approval processes,
• Chemical classification studies,
• And regulatory compliance.

Studies Conducted in Compliance with OECD Guidelines

Repeated-Dose Toxicity tests conducted at NanoTox are carried out in accordance with internationally recognized OECD test guidelines. The primary methods used include:

• OECD 407 – Repeated-Dose 28-Day Oral Toxicity Study in Rodents
• OECD 408 – Repeated-Dose 90-Day Oral Toxicity Study in Rodents
• OECD 409 – Repeated-Dose 90-Day Oral Toxicity Study in Non-Rodents

Studies conducted in accordance with these guidelines ensure the generation of reliable toxicological data accepted by international authorities.

GLP-Compliant In Vivo Testing Services

Studies conducted in accordance with GLP principles ensure quality and traceability throughout the planning, implementation, monitoring, recording, reporting, and archiving processes.

As NanoTox:

• With our modern laboratory infrastructure,
• Our experienced team of experts,
• Our work processes compliant with international standards,
• And our science- and quality-focused approach, we deliver reliable and reproducible results.

Parameters Evaluated in Repeated-Dose Toxicity Studies

Various clinical, biochemical, and pathological parameters are evaluated in detail throughout the testing period. These include:

• Clinical observations,
• Changes in body weight,
• Feed and water consumption,
• Hematological analyses,
• Clinical biochemistry parameters,
• Organ weights,
• Histopathological examinations.

Through these comprehensive evaluations, the potential toxic effects that the tested product may cause following long-term exposure are analyzed.

Reliable Toxicity Studies with NanoTox

NanoTox conducts Repeated-Dose Toxicity studies in accordance with international quality standards as part of its GLP-compliant in vivo testing services. We offer professional solutions to reliably obtain the scientific data required for product safety and regulatory processes.

For detailed information about Repeated-Dose Toxicity tests and our other toxicology services, please contact NanoTox.