What Is a Skin Sensitization Test?

Skin sensitization tests are important toxicological studies conducted to assess a substance’s potential to cause an allergic reaction following repeated skin contact. Skin sensitization tests are particularly used in safety assessments of cosmetic products, biocidal products, chemical substances, medical devices, pharmaceutical raw materials, and industrial products.

At NanoTox, we offer internationally recognized toxicity testing services using infrastructure compliant with GLP (Good Laboratory Practice) standards.

The Purpose of the Skin Sensitization Test

Skin sensitization studies aim to determine the potential of the tested substance to induce an allergic reaction through the immune system following skin contact.

Through these studies,

• product safety assessments,
• chemical classification processes,
• labeling requirements,
• regulatory and licensing applications,
• and human health risk assessments

are supported by the necessary scientific data.

Studies Conducted in Compliance with OECD Guidelines

Skin Sensitization tests conducted at NanoTox are performed in accordance with internationally recognized OECD test guidelines. The primary methods used include:

• OECD 406 – Skin Sensitization
• OECD 429 – Local Lymph Node Assay (LLNA)
• OECD 442C – Direct Peptide Reactivity Assay
• OECD 442D – ARE-Nrf2 Luciferase Test Method
• OECD 442E – Human Cell Line Activation Test

Studies conducted in accordance with these guidelines ensure the generation of reliable toxicological data accepted by global authorities.

GLP-Compliant Testing Services

Studies conducted in accordance with GLP principles ensure quality and traceability throughout the planning, implementation, monitoring, recording, reporting, and archiving processes.

As NanoTox:

• With our modern laboratory infrastructure,
• Our experienced team of experts,
• Our work processes compliant with international standards,
• And our science- and quality-focused approach, we deliver reliable and reproducible results.

Parameters Evaluated in Skin Sensitization Studies

Various immunological and toxicological parameters are evaluated in detail throughout the testing period. These include:

• Observations of allergic reactions,
• Skin reactions,
• Evaluations of erythema and edema,
• Lymph node responses,
• Evaluations of cellular activation,
• Sensitization potential analyses.

Thanks to these comprehensive evaluations, the potential of the tested product to cause allergic reactions is analyzed in detail.

Reliable Toxicity Studies with NanoTox

NanoTox conducts Skin Sensitization studies in accordance with international quality standards as part of its GLP-compliant toxicity testing services. We offer professional solutions to reliably obtain the scientific data required for product safety and regulatory processes.

For detailed information about Skin Sensitization tests and our other toxicology services, please contact NanoTox.