What Is an Acute Oral Toxicity Test?

Toxicity testing is one of the most critical stages in product safety assessments. Acute Oral Toxicity (AOT) tests, conducted particularly during the development of pharmaceuticals, biocidal products, medical devices, chemical substances, and industrial products, aim to identify the potential toxic effects a substance may cause following a single oral dose.

At NanoTox, we conduct internationally recognized in vivo toxicity studies using our infrastructure compliant with GLP (Good Laboratory Practice) standards.

The Purpose of the Acute Oral Toxicity Test

Acute oral toxicity studies evaluate the effects that may occur shortly after a single oral administration of the tested substance. Through these studies, the product’s safety profile is established, enabling the identification of potential risks to human health.

The data obtained plays a significant role in:

• Product safety assessments,
• Hazard classifications,
• Labeling processes,
• Regulatory applications,
• Regulatory compliance.

Studies Conducted in Compliance with OECD Guidelines

Acute Oral Toxicity tests conducted at NanoTox are carried out in accordance with internationally recognized OECD test guidelines. The primary methods used are:

• OECD 420 – Fixed Dose Procedure
• OECD 423 – Acute Toxic Class Method
• OECD 425 – Up-and-Down Procedure.

Studies conducted in accordance with these guidelines ensure the generation of reliable toxicological data accepted by global authorities.

GLP-Compliant In Vivo Testing Services

GLP principles ensure quality and traceability throughout the planning, execution, monitoring, reporting, and archiving of laboratory studies.

At NanoTox:

• With our modern laboratory infrastructure,
• our experienced team of experts,
• our work processes compliant with international standards,
• and our quality-focused approach, we deliver reliable and reproducible results.

Parameters Evaluated in Acute Oral Toxicity Studies

Various clinical and toxicological parameters are closely monitored throughout the test. These include:

• Clinical observations,
• Behavioral changes,
• Body weight monitoring,
• Mortality and morbidity assessments,
• Macroscopic pathological examinations.

Thanks to these comprehensive evaluations, the potential toxic effects of the tested product are analyzed in detail.

Reliable Toxicity Testing with NanoTox

NanoTox conducts Acute Oral Toxicity studies in accordance with GLP-compliant in vivo testing services, adhering to international quality standards. We offer professional solutions to reliably obtain the scientific data required for product safety and regulatory processes.

For detailed information about Acute Oral Toxicity tests and our other toxicology services, please contact NanoTox.